Research Profile- Dr. Yohan Bossé


Research Summary for Dr. Yohan Bossé



Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada

Research Description:

Dr Yohan Bossé is a research scholar from the Heart and Stroke Foundation of Canada, co-director of the Respiratory Health Network Tissue Bank of the FRQS (i.e. the world largest lung tissues bank, and one of the principal investigators of the international Lung eQTL Consortium ( He is the leader of an expanding research group using state-of-the-art technologies in genomics to identify genetic factors and molecular mechanisms leading to cardio-respiratory diseases. His research program focuses on two main themes: 1) genetics of calcific aortic valve stenosis, and 2) genomics of respiratory diseases including smoking-related lung diseases and asthma. His research activities are now expanding in the fields of lung cancer and personalized medicine. The overall goals of this research program are to identify relevant human genes implicated in these chronic and complex diseases, improve our understanding of the diseases processes, and find new molecular targets to treat patients suffering from these disorders.

Most Recent Publications :

Bossé Y, Postma DS, Sin D, Lamontagne M, Couture C, Gaudreault N, Joubert P, Wong V, Elliott M, van den Berge M, Brandsma CA, Tribouley C, Malkov V, Tsou JA, Opiteck GJ, Hogg JC, Sandford AJ, Timens W, Paré PD, Laviolette M. Molecular signature of smoking in human lung tissues. Cancer Research 2012; PubMed 22659451.

Audet A, Côté N, Ducharme V, Couture C, Bossé Y, Després JP, Pibarot P, Mathieu P. Amyloid substance within stenotic aortic valve promotes mineralization. Histopathology 2012; PubMed 22642224.

Bossé Y. Highlights from the latest articles in chronic obstructive pulmonary disease genetics. Personalized Medicine 2012;9(2):181-4.

Côté N*, El Husseini D*, Pépin A, Guauque-Olarte S, Ducharme V, Bouvet C, Bouchard-Cannon P, Gilbert LA, Audet A, Fournier D, Gaudreault N, Derbali H, McKee MD, Simard C, Després JP, Pibarot P, Moreau P, Bossé Y, Mathieu P. ATP acts as a survival signal and prevents the mineralization of aortic valve. Journal of Molecular and Cellular Cardiology 2012;52(5):1191-202.

Gaudreault N, Ducharme V, Lamontagne M, Guauque-Olarte S, Mathieu P, Pibarot P, Bossé Y. Replication of genetic association studies in aortic stenosis in adults. The American Journal of Cardiology 2011;108(9):1305-10.

Zhang Y, Mfuna Endam L, Filali-Mouhim A, Bossé Y, Castano R, Desrosiers M. Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis. The American Journal of Rhinology and Allergy 2011;25(2):49-54.

Guauque-Olarte S, Gaudreault N, Piché ME, Fournier D, Mauriège P, Mathieu P, Bossé Y. The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease. PLoS ONE 2011;6(5):e19908.

Bossé Y, Sin D, Laviolette M, Sandford A, Hogg J, Daley D, Franke L, Nickle D, Timens W, Postma D, Paré P. Hypothesis-driven research on genomic data derived from a large scale lung eQTL mapping study. WebmedCentral LUNG 2010;1(9):WMC00724.